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Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages

United States Patent

October 15, 2013
View the Complete Patent at the US Patent & Trademark Office
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This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.
Hibbs; Michael (Albuquerque, NM), Altman; Susan J. (Albuquerque, NM), Jones; Howland D. T. (Rio Rancho, NM), Savage; Paul B. (Mapleton, UT)
Sandia Corporation (Albuquerque, NM)
12/ 986,215
January 7, 2011
FEDERALLY SPONSORED RESEARCH The United States Government has rights in this invention pursuant to Department of Energy Contract No. DE-AC04-94AL85000 with Sandia Corporation.