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Implantable biomedical devices on bioresorbable substrates

United States Patent

March 4, 2014
View the Complete Patent at the US Patent & Trademark Office
Provided herein are implantable biomedical devices, methods of administering implantable biomedical devices, methods of making implantable biomedical devices, and methods of using implantable biomedical devices to actuate a target tissue or sense a parameter associated with the target tissue in a biological environment. Each implantable biomedical device comprises a bioresorbable substrate, an electronic device having a plurality of inorganic semiconductor components supported by the bioresorbable substrate, and a barrier layer encapsulating at least a portion of the inorganic semiconductor components. Upon contact with a biological environment the bioresorbable substrate is at least partially resorbed, thereby establishing conformal contact between the implantable biomedical device and the target tissue in the biological environment.
Rogers; John A. (Champaign, IL), Kim; Dae-Hyeong (Urbana, IL), Omenetto; Fiorenzo (Wakefield, MA), Kaplan; David L. (Concord, MA), Litt; Brian (Bala Cynwyd, PA), Viventi; Jonathan (Philadelphia, PA), Huang; Yonggang (Glencoe, IL), Amsden; Jason (Eddington, ME)
The Board of Trustees of the University of Illinois (Urbana, IL), Northwestern University (Evanston, IL), Trustees of Tufts College (Medford, MA), The Trustees of the University of Pennsylvania (Philadelphia, PA)
12/ 892,001
September 28, 2010
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with United States governmental support under Award Nos. DE-FG02-07ER46471 and DE-FG02-91ER45439 awarded by The U.S. Department of Energy, and by Contract No. W911 NF-07-1-0618 awarded by the U.S. Army Research Laboratory. The U.S. government has certain rights in the invention.