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Facilitating protein solubility by use of peptide extensions

United States Patent

September 17, 2013
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
Expression vectors for expression of a protein or polypeptide of interest as a fusion product composed of the protein or polypeptide of interest fused at one terminus to a solubility enhancing peptide extension are provided. Sequences encoding the peptide extensions are provided. The invention further comprises antibodies which bind specifically to one or more of the solubility enhancing peptide extensions.
Freimuth; Paul I. (East Setauket, NY), Zhang; Yian-Biao (Middle Island, NY), Howitt; Jason (London, GB)
Brookhaven Science Associates, LLC (Upton, NY)
12/ 684,195
January 8, 2010
GOVERNMENT SUPPORT This invention was made with Government support under contract number DE-AC02-98CH10886, awarded by the U.S. Department of Energy. The Government has certain rights in the invention.