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Data transformation methods for multiplexed assays

United States Patent

8,494,780
July 23, 2013
View the Complete Patent at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
Methods to improve the performance of an array assay are described. A correlation between fluorescence intensity-related parameters and negative control values of the assay is determined. The parameters are then adjusted as a function of the correlation. As a result, sensitivity of the assay is improved without changes in its specificity.
Tammero; Lance F. Bentley (Oakland, CA), Dzenitis; John M. (Danville, CA), Hindson; Benjamin J. (Livermore, CA)
Lawrence Livermore National Security, LLC (Livermore, CA)
12/ 698,785
20110022344
February 2, 2010
STATEMENT OF GOVERNMENT GRANT The United States Government has rights in this invention pursuant to Contract No. DE-AC52-07NA27344 between the United States Department of Energy and Lawrence Livermore National Security, LLC for the operation of Lawrence Livermore National Laboratory.