A non-aqueous single pot synthesis of [.sup.18F]SFB is set forth. The [.sup.18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.
This invention was made with Government support under Grant No. CA086306 awarded by the National Institutes of Health; Grant No. DE-FG02-06ER64249 awarded by the United States Department of Energy. The Government has certain rights in this invention.