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Mass spectrometric immunoassay

United States Patent

July 16, 2013
View the Complete Patent at the US Patent & Trademark Office
Rapid mass spectrometric immunoassay methods for detecting and/or quantifying antibody and antigen analytes utilizing affinity capture to isolate the analytes and internal reference species (for quantification) followed by mass spectrometric analysis of the isolated analyte/internal reference species. Quantification is obtained by normalizing and calibrating obtained mass spectrum against the mass spectrum obtained for an antibody/antigen of known concentration.
Nelson; Randall W. (Phoenix, AZ), Williams; Peter (Phoenix, AZ), Krone; Jennifer Reeve (Granbury, TX)
Intrinsic Bioprobes, Inc. (Tempe, AZ)
13/ 421,633
March 15, 2012
Financial Assistance for some of the work reported herein was provided by the United States Department of Energy under Grant number DEFG02-91ER61127. The United States government may have certain rights to this invention.