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Probe and method for DNA detection

United States Patent

8,476,014
July 2, 2013
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
A hybridization probe containing two linear strands of DNA lights up upon hybridization to a target DNA using silver nanoclusters that have been templated onto one of the DNA strands. Hybridization induces proximity between the nanoclusters on one strand and an overhang on the other strand, which results in enhanced fluorescence emission from the nanoclusters.
Yeh; Hsin-Chih (Los Alamos, NM), Werner; James Henry (Los Alamos, NM), Sharma; Jaswinder Kumar (Los Alamos, NM), Martinez; Jennifer Suzanne (Dixon, NM)
Los Alamos National Security, LLC (Los Alamos, NM)
12/ 932,321
20110212540
February 22, 2011
STATEMENT REGARDING FEDERAL RIGHTS This invention was made with government support under Contract No. DE-AC52-06NA25396 awarded by the U.S. Department of Energy. The government has certain rights in the invention.