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Methods and compositions for targeting macromolecules into the nucleus

United States Patent

June 25, 2013
View the Complete Patent at the US Patent & Trademark Office
Argonne National Laboratory - Visit the Technology Development and Commercialization Website
The present invention includes compositions, methods and kits for directing an agent across the nuclear membrane of a cell. The present invention includes a Karyopherin beta2 translocation motif in a polypeptide having a slightly positively charged region or a slightly hydrophobic region and one or more R/K/H-X.sub.(2-5)-P-Y motifs. The polypeptide targets the agent into the cell nucleus.
Chook; Yuh Min (Dallas, TX)
Board of Regents, The University of Texas System (Austin, TX)
11/ 697,656
April 6, 2007
STATEMENT OF FEDERALLY FUNDED RESEARCH This invention was made with U.S. Government support under Contract No. R01 GM069909 awarded by the NIH and contract W-31-109-ENG-38 awarded by the United States Department of Energy. The government has certain rights in this invention.