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Mosaic protein and nucleic acid vaccines against hepatitis C virus

United States Patent

June 11, 2013
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
The invention relates to immunogenic compositions useful as HCV vaccines. Provided are HCV mosaic polypeptide and nucleic acid compositions which provide higher levels of T-cell epitope coverage while minimizing the occurrence of unnatural and rare epitopes compared to natural HCV polypeptides and consensus HCV sequences.
Yusim; Karina (Santa Fe, NM), Korber; Bette T. M. (Los Alamos, NM), Kuiken; Carla L. (Santa Fe, NM), Fischer; William M. (Santa Fe, NM)
Los Alamos National Security, LLC (Los Alamos, NM)
12/ 893,731
September 29, 2010
STATEMENT AS TO RIGHTS AND INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with government support under Contract No. DE-AC52-06 NA 25396 awarded by the U.S. Department of Energy. The government has certain rights in the invention.