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Method for determining gene knockouts

United States Patent

June 4, 2013
View the Complete Patent at the US Patent & Trademark Office
A method for determining candidates for gene deletions and additions using a model of a metabolic network associated with an organism, the model includes a plurality of metabolic reactions defining metabolite relationships, the method includes selecting a bioengineering objective for the organism, selecting at least one cellular objective, forming an optimization problem that couples the at least one cellular objective with the bioengineering objective, and solving the optimization problem to yield at least one candidate.
Maranas; Costas D. (Port Matilda, PA), Burgard; Anthony R. (State College, PA), Pharkya; Priti (State College, PA)
The Penn State Research Foundation (University Park, PA)
13/ 210,484
August 16, 2011
GRANT REFERENCE This invention was made with government support under Grant No. DE-FG03-01ER25499, awarded by the Department of Energy and under Grant No. BES0120277, awarded by the National Science Foundation. The Government has certain rights in the invention.