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Unnatural reactive amino acid genetic code additions

United States Patent

8,445,446
May 21, 2013
View the Complete Patent at the US Patent & Trademark Office
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
Deiters; Alexander (La Jolla, CA), Cropp; Ashton T. (Bethesda, MD), Chin; Jason W. (Cambridge, GB), Anderson; Christopher J. (San Francisco, CA), Schultz; Peter G. (La Jolla, CA)
The Scripps Research Institute (La Jolla, CA)
13/ 135,129
20120004183
June 23, 2011
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT This invention was made with government support under Grant No. GM 62159 from the National Institutes of Health and support under Grant DE-FG0300ER45812 from the Department of Energy. The government has certain rights to this invention.