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Means and methods for cytometric therapies

United States Patent

March 26, 2013
View the Complete Patent at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
A functionalized tip is incorporated into catheters for the cytometric delivery of cells into the brain and other body parts. For use in the brain, the tip forms part of a neurosurgical probe having a proximal end and a distal end. In addition to the functionalized tip, the probe has at least one cell slurry delivery lumen and a plurality of optical fibers configured along the probe, terminating in the tip to provide the photo-optical capability needed to monitor the viability and physiological behavior of the grafted cells as well as certain characteristics of the cellular environment. Details are also presented of the use of a neurocatheter having a cytometric tip of the type disclosed in the invention, as employed within the context of a feedback and control system for regulating the number of cells delivered to the brain of a patient.
Gillies; George T. (Charlottesville, VA), Fillmore; Helen (Richmond, VA), Broaddus; William C. (Midlothian, VA), Evans, III; Boyd M. (Oak Ridge, TN), Allison; Stephen W. (Knoxville, TN)
UT-Battelle, LLC (Oak Ridge, TN), University of Virginia Patent Foundation (Charlottesville, VA)
12/ 513,258
November 1, 2007
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH This invention was made with United States Government support under Contract No. DE-AC05-00OR22725 between the United States Department of Energy and U.T. Battelle, LLC. The United States Government has certain rights in this invention.