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Enhancement of concentration range of chromatographically detectable components with array detector mass spectrometry

United States Patent

February 19, 2013
View the Complete Patent at the US Patent & Trademark Office
Pacific Northwest National Laboratory - Visit the Technology Commercialization Program Website
Methods and instruments for high dynamic range analysis of sample components are described. A sample is subjected to time-dependent separation, ionized, and the ions dispersed with a constant integration time across an array of detectors according to the ions m/z values. Each of the detectors in the array has a dynamically adjustable gain or a logarithmic response function, producing an instrument capable of detecting a ratio of responses or 4 or more orders of magnitude.
Enke; Christie (Placitas, NM)
STC.UNM (Albuquerque, NM)
13/ 080,392
April 5, 2011
STATEMENT REGARDING GOVERNMENT SPONSORED RESEARCH This invention was made with Government support under Grant No. DE-ACO5-76RL01830, awarded by the Department of Energy--Battelle. The U.S. Government has certain rights in this invention.