Methods and instruments for high dynamic range analysis of sample components are described. A sample is subjected to time-dependent separation, ionized, and the ions dispersed with a constant integration time across an array of detectors according to the ions m/z values. Each of the detectors in the array has a dynamically adjustable gain or a logarithmic response function, producing an instrument capable of detecting a ratio of responses or 4 or more orders of magnitude.
STATEMENT REGARDING GOVERNMENT SPONSORED RESEARCH
This invention was made with Government support under Grant No. DE-ACO5-76RL01830, awarded by the Department of Energy--Battelle. The U.S. Government has certain rights in this invention.