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In vivo imaging of sulfotransferases

United States Patent

February 12, 2013
View the Complete Patent at the US Patent & Trademark Office
Radiolabeled tracers for sulfotransferases (SULTs), their synthesis, and their use are provided. Included are substituted phenols, naphthols, coumarins, and flavones radiolabeled with .sup.18F, .sup.123I, .sup.124I, .sup.125I, or .sup.11C. Also provided are in vivo techniques for using these and other tracers as analytical and diagnostic tools to study sulfotransferase distribution and activity, in health and disease, and to evaluate therapeutic interventions.
Barrio; Jorge R. (Agoura Hills, CA), Kepe; Vladimir (Los Angeles, CA), Small; Gary W. (Los Angeles, CA), Satyamurthy; Nagichettiar (Los Angeles, CA)
The Regents of the University of California (Oakland, CA)
12/ 594,197
March 31, 2008
ACKNOWLEDGEMENT OF GOVERNMENT SUPPORT This application was made with government support under Grant No. DE-FC02-02ER63420 (J. R. Barrio), awarded by the United States Department of Energy. The Government has certain rights in the invention.