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Labeled ALPHA4BETA2 ligands and methods therefor

United States Patent

8,378,109
February 19, 2013
View the Complete Patent at the US Patent & Trademark Office
Contemplated compositions and methods are employed to bind in vitro and in vivo to an .alpha.4.beta.2 nicotinic acetylcholine receptor in a highly selective manner. Where such compounds are labeled, compositions and methods employing such compounds can be used for PET and SPECT analysis. Alternatively, and/or additionally contemplated compounds can be used as antagonists, partial agonists or agonists in the treatment of diseases or conditions associated with .alpha.4.beta..beta.2 dysfunction.
Mukherjee; Jogeshwar (Irvine, CA), Pichika; Ramaiah (Oregon, CA), Potkin; Steven (Irvine, CA), Leslie; Frances (Irvine, CA), Chattopadhyay; Sankha (Bidhannagar, IN)
The Regents of the University of California (Oakland, CA)
11/ 721,145
20090297443
December 1, 2005
This invention was made with government support from the Biologic and Environmental Program, U.S. Department of Energy, Grant number DEFG02-03ER63598. The government may have certain rights in the invention.