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Nucleic acid based fluorescent sensor for mercury detection

United States Patent

February 5, 2013
View the Complete Patent at the US Patent & Trademark Office
A nucleic acid enzyme comprises an oligonucleotide containing thymine bases. The nucleic acid enzyme is dependent on both Hg.sup.2+and a second ion as cofactors, to produce a product from a substrate. The substrate comprises a ribonucleotide, a deoxyribonucleotide, or both.
Lu; Yi (Champaign, IL), Liu; Juewen (Kitchener, CA)
The Board of Trustees of the University of Illinois (Urbana, IL)
12/ 672,833
August 6, 2008
FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This subject matter of this application may have been funded in part under the following research grants and contracts: National Science Foundation Contract Numbers CTS-0120978 and DMI-0328162, and U.S. Department of Energy Contract Number DE-FG02-01-ER63179. The U.S. Government may have rights in this invention.