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Systems for the expression of orthogonal translation components in eubacterial host cells

United States Patent

January 22, 2013
View the Complete Patent at the US Patent & Trademark Office
The invention related to compositions and methods for the in vivo production of polypeptides comprising one or more unnatural amino acids. Specifically, the invention provides plasmid systems for the efficient eubacterial expression of polypeptides comprising one or more unnatural acids at genetically-programmed positions.
Ryu; Youngha (San Diego, CA), Schultz; Peter G. (La Jolla, CA)
The Scripps Research Institute (LaJolla, CA)
13/ 468,736
May 10, 2012
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT This invention was made with government support under Contract No. DE-FG02-03ER46051 awarded by the Department of Energy. The U.S. Government has certain rights to the invention.