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Method to determine transcriptional regulation pathways in organisms

United States Patent

November 6, 2012
View the Complete Patent at the US Patent & Trademark Office
The invention relates to computer-implemented methods and systems for identifying regulatory relationships between expressed regulating polypeptides and targets of the regulatory activities of such regulating polypeptides. More specifically, the invention provides a new method for identifying regulatory dependencies between biochemical species in a cell. In particular embodiments, provided are computer-implemented methods for identifying a regulatory interaction between a transcription factor and a gene target of the transcription factor, or between a transcription factor and a set of gene targets of the transcription factor. Further provided are genome-scale methods for predicting regulatory interactions between a set of transcription factors and a corresponding set of transcriptional target substrates thereof.
Gardner; Timothy S. (Needham, MA), Collins; James J. (Newton, MA), Hayete; Boris (Arlington, MA), Faith; Jeremiah (Boston, MA)
Trustees of Boston University (Boston, MA)
12/ 271,944
November 17, 2008
GOVERNMENT SUPPORT This invention was made with Government Support under Contract No. DE-FG02-04ER63803 awarded by the Department of Energy, Grant No. EF-0425719 awarded by the National Science Foundation and Grant No. HV28178 awarded by the National Institutes of Health. The Government has certain rights in this invention.