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Automated imaging system for single molecules

United States Patent

September 18, 2012
View the Complete Patent at the US Patent & Trademark Office
There is provided a high throughput automated single molecule image collection and processing system that requires minimal initial user input. The unique features embodied in the present disclosure allow automated collection and initial processing of optical images of single molecules and their assemblies. Correct focus may be automatically maintained while images are collected. Uneven illumination in fluorescence microscopy is accounted for, and an overall robust imaging operation is provided yielding individual images prepared for further processing in external systems. Embodiments described herein are useful in studies of any macromolecules such as DNA, RNA, peptides and proteins. The automated image collection and processing system and method of same may be implemented and deployed over a computer network, and may be ergonomically optimized to facilitate user interaction.
Schwartz; David Charles (Madison, WI), Runnheim; Rodney (Madison, WI), Forrest; Daniel (Madison, WI)
Wisconsin Alumni Research Foundation (Madison, WI)
11/ 052,836
February 9, 2005
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT The work described in this disclosure was conducted with United States Government support, grant number DE-FG02-99ER62830, awarded by the Department of Energy. The United States Government has certain rights in the invention(s) of this disclosure.