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Amphiphiles for protein solubilization and stabilization

United States Patent

8,263,754
September 11, 2012
View the Complete Patent at the US Patent & Trademark Office
Argonne National Laboratory - Visit the Technology Development and Commercialization Website
The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
Gellman; Samuel Helmer (Madison, WI), Chae; Pil Seok (Madison, WI), Laible; Philip D. (Villa Park, IL), Wander; Marc J. (Downers Grove, IL)
Wisconsin Alumni Research Foundation (Madison, WI), UChicago Argonne, LLC (Chicago, IL)
12/ 420,701
April 8, 2009
GOVERNMENT SUPPORT This invention was made with government support under Grant No. P01 GM75913, awarded by the National Institutes of Health, Contract No. W-31-109-ENG-38, awarded by the Department of Energy, and Contract No. DE-AC02-06CH11357, awarded by the Department of Energy. The United States Government has certain rights in the invention.