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Synthetic LDL as targeted drug delivery vehicle

United States Patent

August 28, 2012
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides a synthetic LDL nanoparticle comprising a lipid moiety and a synthetic chimeric peptide so as to be capable of binding the LDL receptor. The synthetic LDL nanoparticle of the present invention is capable of incorporating and targeting therapeutics to cells expressing the LDL receptor for diseases associated with the expression of the LDL receptor such as central nervous system diseases. The invention further provides methods of using such synthetic LDL nanoparticles.
Forte; Trudy M. (Berkeley, CA), Nikanjam; Mina (Richmond, CA)
The Regents of the University of California (Oakland, CA), Children's Hospital & Research Center Oakland (Oakland, CA)
12/ 084,845
November 13, 2006
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made during work supported in part by the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. The government has certain rights in this invention.