The present invention provides a fibroblast growth factor heparin-binding analog of the formula: ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
The U.S. Government has a paid-up license in this invention and the right in limited circumstances to require the patent owner to license others on reasonable terms as provided for by the terms of Grant No. 1-R43-HL077039 awarded by the U.S. NHBLI, National Institutes of Health; Cooperative Research and Development Agreement (CRADA) between BioSurface Engineering Technologies, Inc. and Brookhaven Science Associates, LLC, operator of Brookhaven National Laboratory, No. BNL-C-03-01; and U.S. Department of Energy Contract No. DE-AC02-98CH10886.