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Orthogonal translation components for the in vivo incorporation of unnatural amino acids

United States Patent

July 10, 2012
View the Complete Patent at the US Patent & Trademark Office
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
Schultz; Peter G. (La Jolla, CA), Xie; Jianming (San Diego, CA), Zeng; Huaqiang (San Diego, CA)
The Scripps Research Institute (La Jolla, CA)
11/ 665,083
October 27, 2005
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY A portion of the work described herein was supported by grant numbers GM62159, and AI66507 from the National Institutes of Health, and grant number ER46051 from the Department of Energy. The United States Government has certain rights to this invention.