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Engineered enzymatically active bacteriophages and methods of uses thereof

United States Patent

May 22, 2012
View the Complete Patent at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
The present invention provides engineered bacteriophages that express at least one biofilm degrading enzyme on their surface and uses thereof for degrading bacterial biofilms. The invention also provides genetically engineered bacteriophages expressing the biofilm degrading enzymes and proteins necessary for the phage to replicate in different naturally occurring biofilm producing bacteria. The phages of the invention allow a method of biofilm degradation by the use of one or only a few administration of the phage because the system using these phages is self perpetuating, and capable of degrading biofilm even when the concentration of bacteria within the biofilm is low.
Collins; James J (Newton, MA), Kobayashi; Hideki (Yokohama, JP), Kearn; Mads (Ottawa, CA), Araki; Michihiro (Minatoku, JP), Friedland; Ari (Boston, MA), Lu; Timothy Kuan-Ta (Palo Alto, CA)
Trustees of Boston University (Boston, MA), Massachusetts Institute of Technology (Cambridge, MA)
11/ 662,551
September 12, 2005
GOVERNMENT SUPPORT This invention was made with Government Support under Grant No. DE-AC05-00OR22725 awarded by the Department of Energy, and Grant No. EIA-0130331 awarded by the National Science Foundation. The United States Government has certain rights in the invention.