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Nucleic acids, compositions and uses thereof

United States Patent

February 21, 2012
View the Complete Patent at the US Patent & Trademark Office
The subject invention provides at least one nucleic acid sequence encoding an aldouronate-utilization regulon isolated from Paenibacillus sp. strain JDR-2, a bacterium which efficiently utilizes xylan and metabolizes aldouronates (methylglucuronoxylosaccharides). The subject invention also provides a means for providing a coordinately regulated process in which xylan depolymerization and product assimilation are coupled in Paenibacillus sp. strain JDR-2 to provide a favorable system for the conversion of lignocellulosic biomass to biobased products. Additionally, the nucleic acid sequences encoding the aldouronate-utilization regulon can be used to transform other bacteria to form organisms capable of producing a desired product (e.g., ethanol, 1-butanol, acetoin, 2,3-butanediol, 1,3-propanediol, succinate, lactate, acetate, malate or alanine) from lignocellulosic biomass.
Preston, III; James F. (Micanopy, FL), Chow; Virginia (Gainesville, FL), Nong; Guang (Gainesville, FL), Rice; John D. (Gainesville, FL), St. John; Franz J. (Baltimore, MD)
University of Florida Research Foundation, Inc. (Gainesville, FL)
12/ 256,155
October 22, 2008
The subject invention was made with government support under research projects supported by U.S. Department of Energy grants DE-FG-02GO12026, DE FC36-99GO10476 and DE FC36-00GO10594. The government has certain rights in this invention.