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Detection of molecular interactions

United States Patent

February 14, 2012
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
A method and assay are described for measuring the interaction between a ligand and an analyte. The assay can include a suspension of colloidal particles that are associated with a ligand of interest. The colloidal particles are maintained in the suspension at or near a phase transition state from a condensed phase to a dispersed phase. An analyte to be tested is then added to the suspension. If the analyte binds to the ligand, a phase change occurs to indicate that the binding was successful.
Groves; John T. (Berkeley, CA), Baksh; Michael M. (Fremont, CA), Jaros; Michal (Brno, CH)
The Regents of the University of California (Oakland, CA)
10/ 581,371
December 6, 2004
STATEMENT OF GOVERNMENTAL SUPPORT This invention was made during work supported by the U.S. Department of Energy at Lawrence Berkeley National Laboratory under contract No. DE-AC03-76SF00098. The government has certain rights in this invention.