A method and assay are described for measuring the interaction between a ligand and an analyte. The assay can include a suspension of colloidal particles that are associated with a ligand of interest. The colloidal particles are maintained in the suspension at or near a phase transition state from a condensed phase to a dispersed phase. An analyte to be tested is then added to the suspension. If the analyte binds to the ligand, a phase change occurs to indicate that the binding was successful.
STATEMENT OF GOVERNMENTAL SUPPORT
This invention was made during work supported by the U.S. Department of Energy at Lawrence Berkeley National Laboratory under contract No. DE-AC03-76SF00098. The government has certain rights in this invention.