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Laser desorption ionization and peptide sequencing on laser induced silicon microcolumn arrays

United States Patent

December 27, 2011
View the Complete Patent at the US Patent & Trademark Office
The present invention provides a method of producing a laser-patterned silicon surface, especially silicon wafers for use in laser desorption ionization (LDI-MS) (including MALDI-MS and SELDI-MS), devices containing the same, and methods of testing samples employing the same. The surface is prepared by subjecting a silicon substrate to multiple laser shots from a high-power picosecond or femtosecond laser while in a processing environment, e.g., underwater, and generates a remarkable homogenous microcolumn array capable of providing an improved substrate for LDI-MS.
Vertes; Akos (Reston, VA), Chen; Yong (San Diego, CA)
The George Washington University (Washington, DC)
11/ 674,671
February 14, 2007
STATEMENT OF GOVERNMENTAL INTEREST The U.S. Government has an interest in this invention by virtue of a grant from the Department of Energy (Grant # DE-FG02-01 ER15129).