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Method and apparatus for sustaining viability of biological cells on a substrate

United States Patent

December 13, 2011
View the Complete Patent at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
Carbon NanoFiber Systems for Tissue Interfacing
A method for the transient transformation of a living biological cell having an intact cell membrane defining an intracellular domain, and an apparatus for the transient transformation of biological cells. The method and apparatus include introducing a compartmentalized extracellular component fixedly attached to a cellular penetrant structure to the intracellular domain of the cell, wherein the cell is fixed in a predetermined location and wherein the component is expressed within in the cell while being retained within the compartment and wherein the compartment restricts the mobility and interactions of the component within the cell and prevents transference of the component to the cell.
McKnight; Timothy E. (Greenback, TN), Melechko; Anatoli V. (Oak Ridge, TN), Simpson; Michael L. (Knoxville, TN)
UT-Battelle, LLC (Oak Ridge, TN)
11/ 624,040
January 17, 2007
The United States Government has rights in this invention pursuant to contract no. DE-AC05-00OR22725 between the United States Department of Energy and UT-Battelle, LLC.