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Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins

United States Patent

December 6, 2011
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
Haynes; Barton F. (Durham, NC), Gao; Feng (Durham, NC), Korber; Bette T. (Los Alamos, NM), Hahn; Beatrice H. (Birmingham, AL), Shaw; George M. (Birmingham, AL), Kothe; Denise (Birmingham, AL), Li; Ying Ying (Hoover, AL), Decker; Julie (Alabaster, AL), Liao; Hua-Xin (Chapel Hill, NC)
Duke University (Durham, NC), The Regents of the University of California (Oakland, CA), The University of Alabama at Birmingham Research Foundation (Birmingham, AL)
10/ 572,638
September 17, 2004
This invention was made with Government support under Contract No. DE-AC52-06NA25396 awarded by the U.S. Department of Energy. The Government has certain rights in the invention.