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Methods for magnetic resonance analysis using magic angle technique

United States Patent

November 22, 2011
View the Complete Patent at the US Patent & Trademark Office
Pacific Northwest National Laboratory - Visit the Technology Commercialization Program Website
Methods of performing a magnetic resonance analysis of a biological object are disclosed that include placing the object in a main magnetic field (that has a static field direction) and in a radio frequency field; rotating the object at a frequency of less than about 100 Hz around an axis positioned at an angle of about' relative to the main magnetic static field direction; pulsing the radio frequency to provide a sequence that includes a phase-corrected magic angle turning pulse segment; and collecting data generated by the pulsed radio frequency. In particular embodiments the method includes pulsing the radio frequency to provide at least two of a spatially selective read pulse, a spatially selective phase pulse, and a spatially selective storage pulse. Further disclosed methods provide pulse sequences that provide extended imaging capabilities, such as chemical shift imaging or multiple-voxel data acquisition.
Hu; Jian Zhi (Richland, WA), Wind; Robert A. (Kennewick, WA), Minard; Kevin R. (Kennewick, WA), Majors; Paul D. (Kennewick, WA)
Battelle Memorial Institute (Richland, WA)
11/ 562,390
November 21, 2006
STATEMENT OF GOVERNMENT SUPPORT This invention was made with United States Government support under Contract DE-AC0676RLO1830 and Grant 22342 KP-14-02-01 awarded by the U.S. Department of Energy, by the National Institute of Biomedical Imaging and Bioengineering under Grant 5 R21 EB003293, and by Pacific Northwest National Laboratory Directed Research and Development (LDRD) and Individual Research and Development (IR&D). The United States Government has certain rights in the invention.