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Synthetic peptides that cause F-actin bundling and block actin depolymerization

United States Patent

October 18, 2011
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Synthetic peptides derived from sucrose synthase, and having homology to actin and actin-related proteins, sharing a common motif, useful for causing acting bundling and preventing actin depolymerization. Peptides exhibiting the common motif are described, as well as specific synthetic peptides which caused bundled actin and inhibit actin depolymerization. These peptides can be useful for treating a subject suffering from a disease characterized by cells having neoplastic growth, for anti-cancer therapeutics, delivered to subjects solely, or concomitantly or sequentially with other known cancer therapeutics. These peptides can also be used for stabilizing microfilaments in living cells and inhibiting growth of cells.
Sederoff; Heike (Raleigh, NC), Huber; Steven C (Savoy, IL), Larabell; Carolyn A (Berkeley, CA)
The Regents of the University of California (Oakland, CA), North Carolina State University (Raleigh, NC), U.S. Department of Agricultue/NCAUR (Washington, DC)
10/ 576,757
October 20, 2004
STATEMENT OF GOVERNMENTAL SUPPORT This invention was made during work supported by the U.S. Department of Energy under Contract Nos. DE-AC03-76SF00098 and DE-AI01-91ER20031 and the USDA-ARS under DOE Contract No. DE-AI05-91ER20031. The government has certain rights in this invention.