Synthetic peptides derived from sucrose synthase, and having homology to actin and actin-related proteins, sharing a common motif, useful for causing acting bundling and preventing actin depolymerization. Peptides exhibiting the common motif are described, as well as specific synthetic peptides which caused bundled actin and inhibit actin depolymerization. These peptides can be useful for treating a subject suffering from a disease characterized by cells having neoplastic growth, for anti-cancer therapeutics, delivered to subjects solely, or concomitantly or sequentially with other known cancer therapeutics. These peptides can also be used for stabilizing microfilaments in living cells and inhibiting growth of cells.
STATEMENT OF GOVERNMENTAL SUPPORT
This invention was made during work supported by the U.S. Department of Energy under Contract Nos. DE-AC03-76SF00098 and DE-AI01-91ER20031 and the USDA-ARS under DOE Contract No. DE-AI05-91ER20031. The government has certain rights in this invention.