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Hydroxyapatite-binding peptides for bone growth and inhibition

United States Patent

September 20, 2011
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Hydroxyapatite (HA)-binding peptides are selected using combinatorial phage library display. Pseudo-repetitive consensus amino acid sequences possessing periodic hydroxyl side chains in every two or three amino acid sequences are obtained. These sequences resemble the (Gly-Pro-Hyp).sub.x repeat of human type I collagen, a major component of extracellular matrices of natural bone. A consistent presence of basic amino acid residues is also observed. The peptides are synthesized by the solid-phase synthetic method and then used for template-driven HA-mineralization. Microscopy reveal that the peptides template the growth of polycrystalline HA crystals .about.40 nm in size.
Bertozzi; Carolyn R. (Berkeley, CA), Song; Jie (Shrewsbury, MA), Lee; Seung-Wuk (Walnut Creek, CA)
The Regents of the University of California (Oakland, CA)
11/ 720,427
November 29, 2005
STATEMENT OF GOVERNMENTAL SUPPORT This invention was made during work supported by U.S. Department of Energy under Contract Nos. DE-AC03-76SF00098 and DE-AC02-05CH11231. The government has certain rights in this invention.