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Methods and compositions for the production of orthogonal tRNA-aminoacyl-tRNA synthetase pairs

United States Patent

September 6, 2011
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
Schultz; Peter G. (La Jolla, CA), Wang; Lei (San Diego, CA), Anderson; John Christopher (San Diego, CA), Chin; Jason W. (San Diego, CA), Liu; David R. (Lexington, MA), Magliery; Thomas J. (North Haven, CT), Meggers; Eric L. (Philadelphia, PA), Mehl; Ryan Aaron (San Diego, CA), Pastrnak; Miro (San Diego, CA), Santoro; Stephen William (San Diego, CA), Zhang; Zhiwen (San Diego, CA)
The Scripps Research Institute (La Jolla, CA), The Regents of the University of California (Oakland, CA)
11/ 978,154
October 26, 2007
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT The invention was made with United States Government support under Grant No. N0001498F0402 from the Office of Naval Research, Contract No. NIH GM62159 from the National Institutes of Health, and Contract Nos. DE-FG03-00ER45812, DE-AC03-76SF00098 from the Department of Energy. The United States Government has certain rights in the invention.