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Site-specific incorporation of redox active amino acids into proteins

United States Patent

August 30, 2011
View the Complete Patent at the US Patent & Trademark Office
Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided. Methods for identifying these orthogonal pairs are also provided along with methods of producing proteins with redox active amino acids using these orthogonal pairs.
Alfonta; Lital (San Diego, CA), Schultz; Peter G. (La Jolla, CA), Zhang; Zhiwen (Austin, TX)
The Scripps Research Institute (La Jolla, CA)
10/ 575,991
October 13, 2004
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT This invention was made with government support under Grant No. GM 66494 from the National Institutes of Health and support under Grant DE-FG03-00ER45812 from the Department of Energy. The government may have certain rights to this invention.