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Zymomonas with improved xylose utilization

United States Patent

August 16, 2011
View the Complete Patent at the US Patent & Trademark Office
National Renewable Energy Laboratory - Visit the NREL Technology Transfer Website
Strains of Zymomonas were engineered by introducing a chimeric xylose isomerase gene that contains a mutant promoter of the Z. mobilis glyceraldehyde-3-phosphate dehydrogenase gene. The promoter directs increased expression of xylose isomerase, and when the strain is in addition engineered for expression of xylulokinase, transaldolase and transketolase, improved utilization of xylose is obtained.
Viitanen; Paul V. (West Chester, PA), Tao; Luan (Havertown, PA), Zhang; Yuying (New Hope, PA), Caimi; Perry G. (Kennett Square, PA), McCutchen; Carol M. (Wilmington, DE), McCole; Laura (East Fallowfield, PA), Zhang; Min (Lakewood, CO), Chou; Yat-Chen (Lakewood, CO), Franden; Mary Ann (Centennial, CO)
E. I. du Pont de Nemours and Company (Wilmington, DE), Alliance for Sustainable Energy LLC (Wilmington, DE)
12/ 410,501
March 25, 2009
STATEMENT OF GOVERNMENT RIGHTS This invention was made with United States government support under Contract Nos. 04-03-CA-70224 and DE-FC36-03GO13146 awarded by the Department of Energy. The United States government has certain rights in this invention. Further, the United States Government has rights in this invention under Contract No. DE-AC36-99GO10337 between the United States Department of Energy and the National Renewable Energy Laboratory, a Division of the Midwest Research Institute.