An integral microfluidic device includes an alkali vapor cell and microfluidic channel, which can be used to detect magnetism for nuclear magnetic resonance (NMR) and magnetic resonance imaging (MRI). Small magnetic fields in the vicinity of the vapor cell can be measured by optically polarizing and probing the spin precession in the small magnetic field. This can then be used to detect the magnetic field of in encoded analyte in the adjacent microfluidic channel. The magnetism in the microfluidic channel can be modulated by applying an appropriate series of radio or audio frequency pulses upstream from the microfluidic chip (the remote detection modality) to yield a sensitive means of detecting NMR and MRI.
STATEMENT OF GOVERNMENTAL SUPPORT
This invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the US Department of Energy, under ONR MURI grant No. FD-N090014-05-1-0406, and with funds supplied by the National Institute of Standards and Technology, a non-regulatory federal agency within the US Department of Commerce. The government has certain rights in this invention.