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System, device, and methods for real-time screening of live cells, biomarkers, and chemical signatures

United States Patent

June 7, 2011
View the Complete Patent at the US Patent & Trademark Office
Pacific Northwest National Laboratory - Visit the Technology Commercialization Program Website
An ATR-FTIR device and system are described that defect live-cell responses to stimuli and perturbations in real-time. The system and device can monitor perturbations resulting from exposures to various physical, chemical, and biological materials in real-time, as well as those sustained over a long period of time, including those associated with stimuli having unknown modes-of-action (e.g. nanoparticles). The device and system can also be used to identify specific chemical species or substances that profile cellular responses to these perturbations.
Sundaram; S. Kamakshi (Richland, WA), Riley; Brian J. (West Richland, WA), Weber; Thomas J. (Richland, WA), Sacksteder; Colette A. (West Richland, WA), Addleman; R. Shane (Benton City, WA)
Battelle Memorial Institute (Richland, WA)
12/ 511,833
July 29, 2009
This invention was made with Government support under Contract DE-AC05-76RLO1830 awarded by the U.S. Department of Energy. The Government has certain rights in the invention.