Method and apparatus for screening chemicals using micro x-ray fluorescence. A method for screening a mixture of potential pharmaceutical chemicals for binding to at least one target binder involves flow separating a solution of chemicals and target binders into separated components, exposing them to an x-ray excitation beam, detecting x-ray fluorescence signals from the components, and determining from the signals whether or not a binding event between a chemical and target binder has occurred.
STATEMENT REGARDING FEDERAL RIGHTS
This invention was made with government support under contract number W-7405-ENG- 36 and its successor contract number DE-AC52-06NA25396 awarded by the U.S. Department of Energy. The government has certain rights in the invention.