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Flow method and apparatus for screening chemicals using micro x-ray fluorescence

United States Patent

April 19, 2011
View the Complete Patent at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
Method and apparatus for screening chemicals using micro x-ray fluorescence. A method for screening a mixture of potential pharmaceutical chemicals for binding to at least one target binder involves flow separating a solution of chemicals and target binders into separated components, exposing them to an x-ray excitation beam, detecting x-ray fluorescence signals from the components, and determining from the signals whether or not a binding event between a chemical and target binder has occurred.
Warner; Benjamin P. (Los Alamos, NM), Havrilla; George J. (Los Alamos, NM), Miller; Thomasin C. (Bartlesville, OK), Lewis; Cris (Los Alamos, NM), Mahan; Cynthia A. (Los Alamos, NM), Wells; Cyndi A. (Los Alamos, NM)
Los Alamos National Security, LLC (Los Alamos, NM)
12/ 396,592
March 3, 2009
STATEMENT REGARDING FEDERAL RIGHTS This invention was made with government support under contract number W-7405-ENG- 36 and its successor contract number DE-AC52-06NA25396 awarded by the U.S. Department of Energy. The government has certain rights in the invention.