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Neisseria meningitidis serogroup A capsular polysaccharide acetyltransferase, methods and compositions

United States Patent

7,883,876
February 8, 2011
View the Complete Patent at the US Patent & Trademark Office
Provided are methods for recombinant production of an O-acetyltransferase and methods for acetylating capsular polysaccharides, especially those of a Serogroup A Neisseria meningitidis using the recombinant O-acetyltransferase, and immunogenic compositions comprising the acetylated capsular polysaccharide.
Stephens; David S. (Stone Mountain, GA), Gudlavalleti; Seshu K. (Kensington, MD), Tzeng; Yih-Ling (Atlanta, GA), Datta; Anup K. (San Diego, CA), Carlson; Russell W. (Athens, GA)
11/ 943,326
20090208533
November 20, 2007
ACKNOWLEDGMENT OF FEDERAL RESEARCH SUPPORT This invention was made, at least in part, with funding from the National Institutes of Health (Grant No. A140247) and the Department of Energy (Grant No. DE-FG02-93ER20097). Accordingly, the United States Government has certain rights in this invention.