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Closure for milliliter scale bioreactor

United States Patent

December 14, 2010
View the Complete Patent at the US Patent & Trademark Office
A closure for a microreactor includes a cap that is configured to be inserted into a well of the microreactor. The cap, or at least a portion of the cap, is compliant so as to form a seal with the well when the cap is inserted. The cap includes an aperture that provides an airway between the inside of the well to the external environment when the cap is inserted into the well. A porous plug is inserted in the aperture, e.g., either directly or in tube that extends through the aperture. The porous plug permits gas within the well to pass through the aperture while preventing liquids from passing through to reduce evaporation and preventing microbes from passing through to provide a sterile environment. A one-way valve may also be used to help control the environment in the well.
Klein; David L. (Palo Alto, CA), Laidlaw; Robert D. (Albany, CA), Andronaco; Gregory (Palo Alto, CA), Boyer; Stephen G. (Moss Beach, CA)
Pall Microreactor Technologies, Inc. (Mountain View, CA)
11/ 450,855
June 9, 2006
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT The U.S. Government has a paid-up license in this invention and the right in limited circumstances to require the patent owner to license others on reasonable terms as provided for by the terms of contract No. DE-FG02-04ER83963 awarded by the Department of Energy (DOE).