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Functionalized apertures for the detection of chemical and biological materials

United States Patent

December 14, 2010
View the Complete Patent at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
Disclosed are nanometer to micron scale functionalized apertures constructed on a substrate made of glass, carbon, semiconductors or polymeric materials that allow for the real time detection of biological materials or chemical moieties. Many apertures can exist on one substrate allowing for the simultaneous detection of numerous chemical and biological molecules. One embodiment features a macrocyclic ring attached to cross-linkers, wherein the macrocyclic ring has a biological or chemical probe extending through the aperture. Another embodiment achieves functionalization by attaching chemical or biological anchors directly to the walls of the apertures via cross-linkers.
Letant; Sonia E. (Livermore, CA), van Buuren; Anthony W. (Livermore, CA), Terminello; Louis J. (Danville, CA), Thelen; Michael P. (Danville, CA), Hope-Weeks; Louisa J. (Brentwood, CA), Hart; Bradley R. (Brentwood, CA)
Lawrence Livermore National Security, LLC (Livermore, CA)
10/ 677,395
October 1, 2003
The United States Government has rights in this invention pursuant to Contract No. W-7405-ENG-48 between the United States Department of Energy and the University of California for the operation of Lawrence Livermore National Laboratory.