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Study of polymer molecules and conformations with a nanopore

United States Patent

December 7, 2010
View the Complete Patent at the US Patent & Trademark Office
The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.
Golovchenko; Jene A. (Lexington, MA), Li; Jiali (Fayetteville, AR), Stein; Derek (Delft, NL), Gershow; Marc H. (Cambridge, MA)
President and Fellows of Harvard College (Cambridge, MA)
10/ 918,959
August 16, 2004
STATEMENT AS TO FEDERALLY SPONSORED RESEARCH This invention was sponsored by NSF grant No. 0073590, AFRL grant No. F49620-01-1-0467 and the Department of Energy Grant No. DE-FG02-01ER45922. The government has certain rights in this invention.