The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.
STATEMENT AS TO FEDERALLY SPONSORED RESEARCH
This invention was sponsored by NSF grant No. 0073590, AFRL grant No. F49620-01-1-0467 and the Department of Energy Grant No. DE-FG02-01ER45922. The government has certain rights in this invention.