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Nucleic acids encoding antifungal polypeptides and uses thereof

United States Patent

November 2, 2010
View the Complete Patent at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Compositions and methods for protecting a plant from a pathogen, particularly a fungal pathogen, are provided. Compositions include an amino acid sequence, and variants and fragments thereof, for an antipathogenic polypeptide that was isolated from a fungal fermentation broth. Nucleic acid molecules that encode the antipathogenic polypeptides of the invention, and antipathogenic domains thereof, are also provided. A method for inducing pathogen resistance in a plant using the nucleotide sequences disclosed herein is further provided. The method comprises introducing into a plant an expression cassette comprising a promoter operably linked to a nucleotide sequence that encodes an antipathogenic polypeptide of the invention. Compositions comprising an antipathogenic polypeptide or a transformed microorganism comprising a nucleic acid of the invention in combination with a carrier and methods of using these compositions to protect a plant from a pathogen are further provided. Transformed plants, plant cells, seeds, and microorganisms comprising a nucleotide sequence that encodes an antipathogenic polypeptide of the invention are also disclosed.
Altier; Daniel J. (Granger, IA), Ellanskaya; I. A. (Kyiv, UA), Gilliam; Jacob T. (Norwalk, IA), Hunter-Cevera; Jennie (Elliott City, MD), Presnail; James K (Avondale, PA), Schepers; Eric (Port Deposit, MD), Simmons; Carl R. (Des Moines, IA), Torok; Tamas (Richmond, CA), Yalpani; Nasser (Johnston, IA)
Pioneer Hi-Bred International, Inc. (Johnston, IA), E.I. du Pont de Nemours and Company (Wilmington, DE), The Regents of the University of California (Oakland, CA)
12/ 503,952
July 16, 2009
FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with government support under contract number DE-AC02-05CH11231 awarded by the United States Department of Energy. The government has certain rights in the invention.