Skip to Content
Find More Like This
Return to Search

Methods for assisting recovery of damaged brain and spinal cord and treating various diseases using arrays of x-ray microplanar beams

United States Patent

June 29, 2010
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
A method of assisting recovery of an injury site of the central nervous system (CNS) or treating a disease includes providing a therapeutic dose of X-ray radiation to a target volume through an array of parallel microplanar beams. The dose to treat CNS injury temporarily removes regeneration inhibitors from the irradiated site. Substantially unirradiated cells surviving between beams migrate to the in-beam portion and assist recovery. The dose may be staggered in fractions over sessions using angle-variable intersecting microbeam arrays (AVIMA). Additional doses are administered by varying the orientation of the beams. The method is enhanced by injecting stem cells into the injury site. One array or the AVIMA method is applied to ablate selected cells in a target volume associated with disease for palliative or curative effect. Atrial fibrillation is treated by irradiating the atrial wall to destroy myocardial cells while continuously rotating the subject.
Dilmanian; F. Avraham (Yaphank, NY), Anchel; David J. (Rocky Point, NY), Gaudette; Glenn (Holden, MA), Romanelli; Pantaleo (Monteroduni, IT), Hainfeld; James (Shoreham, NY)
The United States of America as represented by the United States Department of Energy (Washington, DC), N/A (
11/ 884,158
February 10, 2006
STATEMENT OF GOVERNMENT LICENSE RIGHTS This invention was made with Government support under contract number DE-AC02-98CH10886, awarded by the U.S. Department of Energy. The Government has certain rights in the invention.