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Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production

United States Patent

June 22, 2010
View the Complete Patent at the US Patent & Trademark Office
National Renewable Energy Laboratory - Visit the NREL Technology Transfer Website
A strain of xylose-utilizing Zymomonas was engineered with a genetic modification to the glucose-fructose oxidoreductase gene resulting in reduced expression of GFOR enzyme activity. The engineered strain exhibits reduced production of xylitol, a detrimental by-product of xylose metabolism. It also consumes more xylose and produces more ethanol during mixed sugar fermentation under process-relevant conditions.
Viitanen; Paul V. (West Chester, PA), Chou; Yat-Chen (Lakewood, CO), McCutchen; Carol M. (Wilmington, DE), Zhang; Min (Lakewood, CO)
E. I. du Pont de Nemours and Company (Wilmington, DE), Alliance for Sustainable Energy LLC (Golden, CO)
11/ 862,566
September 27, 2007
STATEMENT OF GOVERNMENT RIGHTS This invention was made with United States government support under Contract Nos. 04-03-CA-70224 and DE-FC36-03GO13146 awarded by the Department of Energy. The government has certain rights in this invention.