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Non-immunogenic, hydrophilic/cationic block copolymers and uses thereof

United States Patent

May 18, 2010
View the Complete Patent at the US Patent & Trademark Office
The present invention provides novel non-immunogenic, hydrophilic/cationic block copolymers comprising a neutral-hydrophilic polymer and a cationic polymer, wherein both polymers have well-defined chain-end functionality. A representative example of such a block copolymer comprises poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) and poly(N-[3-(dimethylamino)propyl]methacrylamide) (PDMAPMA). Also provided is a synthesis method thereof in aqueous media via reversible addition fragmentation chain transfer (RAFT) polymerization. Further provided are uses of these block copolymers as drug delivery vehicles and protection agents.
Scales; Charles W. (San Ramon, CA), Huang; Faqing (Hattiesburg, MS), McCormick; Charles L. (Hattiesburg, MS)
The University of Southern Mississippi (Hattiesburg, MS)
11/ 725,964
March 20, 2007
The United States government may own rights to the present invention pursuant to grant numbers DMR-0213883 from the MRSEC program of the National Science Foundation and DE-FC26-01BC15317 from the U.S. Department of Energy.