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Computational method and system for modeling, analyzing, and optimizing DNA amplification and synthesis

United States Patent

May 4, 2010
View the Complete Patent at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
A computational method and computer-based system of modeling DNA synthesis for the design and interpretation of PCR amplification, parallel DNA synthesis, and microarray chip analysis. The method and system include modules that address the bioinformatics, kinetics, and thermodynamics of DNA amplification and synthesis. Specifically, the steps of DNA selection, as well as the kinetics and thermodynamics of DNA hybridization and extensions, are addressed, which enable the optimization of the processing and the prediction of the products as a function of DNA sequence, mixing protocol, time, temperature and concentration of species.
Vandersall; Jennifer A. (Livermore, CA), Gardner; Shea N. (San Leandro, CA), Clague; David S. (Livermore, CA)
Lawrence Livermore National Security, LLC (Livermore, CA)
10/ 840,779
May 5, 2004
The United States Government has rights in this invention pursuant to Contract No. W-7405-ENG-48 between the United States Department of Energy and the University of California for the operation of Lawrence Livermore National Laboratory.