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Synthetic heparin-binding factor analogs

United States Patent

April 20, 2010
View the Complete Patent at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two trifunctional amino acid residues, which peptide chain or chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a linker, which may be a hydrophobic linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.
Pena; Louis A. (Poquott, NY), Zamora; Paul O. (Gaithersburg, MD), Lin; Xinhua (Plainview, NY), Glass; John D. (Shoreham, NY)
BioSurface Engineering Technologies, Inc. (Rockville, MD), Brookhaven Science Associates (Upton, NY)
10/ 644,703
August 19, 2003
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT This invention was made with United States Government support under contract number DE-AC02-98CH10886, awarded by the U.S. Department of Energy. The United States Government has certain rights in the invention.