The present invention relates to compositions and methods for cancer diagnosis, treatment and drug screening. In particular, the present invention provides compositions and methods for targeting the nuclear translocation of IkB kinase-.alpha. (IKK.alpha.) and the IKK.alpha.-mediated suppression of Maspin expression observed in metastatic prostate cancer cells.
This invention was made in part with Government support from Grant No. DE-FG03-86ER60429, awarded by the Department of Energy. As such the United States Government has certain rights in this invention.