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Identification of cancer protein biomarkers using proteomic techniques

United States Patent

February 23, 2010
View the Complete Patent at the US Patent & Trademark Office
The claimed invention describes methods to diagnose or aid in the diagnosis of cancer. The claimed methods are based on the identification of biomarkers which are particularly well suited to discriminate between cancer subjects and healthy subjects. These biomarkers were identified using a unique and novel screening method described herein. The biomarkers identified herein can also be used in the prognosis and monitoring of cancer. The invention comprises the use of leptin, prolactin, OPN and IGF-II for diagnosing, prognosis and monitoring of ovarian cancer.
Mor; Gil G. (Cheshire, CT), Ward; David C. (Las Vegas, NV), Bray-Ward; Patricia (Las Vegas, NV)
Yale University (New Haven, CT)
11/ 037,889
January 18, 2005
FUNDING This invention was made with government support under grant number DE-FG02-ER63462 awarded by the United States Department of Energy. The government has certain rights in the invention.